Tumor necrosis factor-α decreases EC-SOD expression through DNA methylation

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Tumor necrosis factor-α decreases EC-SOD expression through DNA methylation

Extracellular-superoxide dismutase (EC-SOD) is a secreted antioxidative enzyme, and its presence in vascular walls may play an important role in protecting the vascular system against oxidative stress. EC-SOD expression in cultured cell lines is regulated by various cytokines including tumor necrosis factor-α (TNF-α). TNF-α is a major mediator of pathophysiological conditions and may induce or ...

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ژورنال

عنوان ژورنال: Journal of Clinical Biochemistry and Nutrition

سال: 2017

ISSN: 0912-0009,1880-5086

DOI: 10.3164/jcbn.16-111